The Effect of Human Blood Plasma Conditioning Films on Platelet Transfusion Bag Surface Properties

Transfusion-associated bacterial infections continue to occur which may be due the formation of biofilms on inner surface blood bag. Plasticized poly (vinyl chloride) (p-PVC) platelet storage bags in three roughness states (rough, smooth and flattened) were used determine effect that a conditioning film (CF) human plasma had properties its interaction with Staphylococcus epidermidis Serratia marcescens. SEM optical profilometry determined changes roughness, whilst EDX ATR-FTIR chemistry. The physicochemistry surfaces bacteria was assessed using contact angle measurements MATH assays respectively. When applied rougher surface, CF reduced topography, masked certain chemistry features made more hydrophilic. adhesion most hydrocarbons. combined bacteria, physicochemical changed similarly those alone, significant observed after 24 h especially Ser. results demonstrated presence also microbial interactions bag surface.